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Pramocaine hydrochloride
Pramocaine hydrochloride (Pramoxine HCl), a topical anesthetic, is served as an antipruritic.
Catalog No. T0460Cas No. 637-58-1
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Purity:99.57%
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Pramocaine hydrochloride
Catalog No. T0460Alias Pramoxine hydrochloride, Pramoxine HClCas No. 637-58-1
Pramocaine hydrochloride (Pramoxine HCl), a topical anesthetic, is served as an antipruritic.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $30 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Pramocaine hydrochloride (Pramoxine HCl), a topical anesthetic, is served as an antipruritic. |
| In vitro | When administered to canines exhibiting dyspnea (breathing difficulty) and tremors, Pramoxine elicited specific changes in skin temperature at which the activation and suppression of panting and shivering occur. These changes are thought to be mediated by peripheral nerves that control the terminal mechanisms of thermoregulation. In studies on guinea pig ileum, Pramoxine (1.7 mM) demonstrated a lesser reduction in response to Substance P compared to its effects on responses to acetylcholine, BaCl2, and histamine. Pramoxine has been identified as having anesthetic inhibitory potency, with a pKa of 6.4 in guinea pig ileum. |
| In vivo | Pramoxine is frequently used in conjunction with Hydrocortisone, Colloidal oatmeal, Menthol, and Petrolatum. |
| Alias | Pramoxine hydrochloride, Pramoxine HCl |
| Molecular Weight | 329.86 |
| Formula | C17H27NO3·HCl |
| Cas No. | 637-58-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 75 mg/mL (227.37 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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